Initially 100 mg, followed by 50 mg every 12 hr by IV infusion over approx 30-60 min for 5-14 days. Hepatic impairment 100 mg followed by 25 mg every 12 hr.
Known hypersensitivity to tetracyclines. Discontinue use if Clostridium difficile-associated diarrhoea is suspected or confirmed. Pseudomembranous colitis; pancreatitis; permanent tooth discoloration during tooth development; photosensitivity, pseudotumor cerebri, anti-anabolic action. Superinfection or overgrowth of non-susceptible organisms including fungi. Severe hepatic impairment. Not to be used during pregnancy. Lactation. Not recommended in childn <18 yr.
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